Independent Clinical Studies on melatonin formulations
manufactured by Penn
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Study |
Formulations employed |
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Details of HTA project in progress The use of melatonin in children with Neuro-Developmental disorders and impaired sleep; a randomised, double-blind, placebo-controlled, parallel Study (MENDS). Information can be found at: http://www.hta.ac.uk/project/1522.asp |
0.5mg capsules 2mg capsules 6mg capsules 12mg capsules |
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Shah T et al. Administration of melatonin mixed with soft food and liquids for children with neurodevelopmental difficulties. Developmental Medicine & Child Neurology 2008, Volume 50 Issue 11, 845 – 849
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0.5mg capsules 2mg capsules 6mg capsules 12mg capsules |
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O'Callaghan FJK et al. Use of melatonin to treat sleep disorders in tuberous sclerosis. Developmental Medicine & Child Neurology
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5mg capsules |
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Ross C et al. Melatonin treatment for sleep disorders in children with neurodevelopmental disorders: an observational study. Developmental Medicine & Child Neurology
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2.5mg capsules 5mg capsules |
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Garstang J and Wallis M. Randomized controlled trial of melatonin for children with autistic spectrum disorders and sleep problems. Child Care, Health and Development,
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5mg capsules |
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Kayumov L et al Randomized, Double-Blind, Placebo-Controlled Crossover Study of the Effect of Exogenous Melatonin on Delayed Sleep Phase Syndrome. Psychosomatic Medicine 2001, 63: 40–48
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5mg capsules |
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SW Lockley, D J Skene, K James, K Thapan, J Wright and J Arendt. Melatonin administration can entrain the free-running circadian system of blind subjects. Journal of Endocrinology (2000) 164, R1–R6
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5mg capsules |
General Reviews on Melatonin
Jan JE et al. Developmental Medicine & Child Neurology 1999, 41: 491-500
Turk J. J. Med. Genet. 2003:40:793-796
DL Waldron, D Bramble and P Gringras. Arch. Dis Child. 2005:90:1206-1207
Please note that Penn does not accept any responsibility for the accuracy of information contained in these independent publications and external websites.