Study

Formulations employed

Details of HTA project in progress

The use of melatonin in children with Neuro-Developmental disorders and impaired sleep; a randomised, double-blind, placebo-controlled, parallel Study (MENDS).

Information can be found at: http://www.hta.ac.uk/project/1522.asp

0.5mg capsules

2mg capsules

6mg capsules

12mg capsules

Shah T et al.

Administration of melatonin mixed with soft food and liquids for children with neurodevelopmental difficulties.

Developmental Medicine & Child Neurology 2008, Volume 50 Issue 11, 845 – 849

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0.5mg capsules

2mg capsules

6mg capsules

12mg capsules

O'Callaghan FJK et al.

Use of melatonin to treat sleep disorders in tuberous sclerosis.

Developmental Medicine & Child Neurology
1999,41:123-126

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5mg capsules

Ross C et al.

Melatonin treatment for sleep disorders in children with neurodevelopmental disorders: an observational study.

Developmental Medicine & Child Neurology
2002, 44: 339-344

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2.5mg capsules

5mg capsules

Garstang J and Wallis M.

Randomized controlled trial of melatonin for children with autistic spectrum disorders and sleep problems.

Child Care, Health and Development,
2006, 32:5, 585-589

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5mg capsules

Kayumov L et al

Randomized, Double-Blind, Placebo-Controlled Crossover Study of the Effect of Exogenous Melatonin on Delayed Sleep Phase Syndrome.

Psychosomatic Medicine 2001, 63: 40–48

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5mg capsules

SW Lockley, D J Skene, K James, K Thapan, J Wright and J Arendt.

Melatonin administration can entrain the free-running circadian system of blind subjects.

Journal of Endocrinology (2000) 164, R1–R6

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5mg capsules